In Greek Mythology Clotho is the one of the Three Fates or Moirai who spins the thread of human life; in our biology Klotho is a trans-membrane receptor structure, parts of which also circulate in our blood, that influences lifespan in many ways.

For those who want to keep up with developments in the use of Klotho as a tool for rejuvenation, here is a decent overview of Klotho and its potential for therapeutics to counter aging from ILB-America.com: Read More

Two practical ways to boost Klotho production in most cell types are fairly simple to implement. The first is to increase levels of Vitamin D3 through supplementation. After learning of the many ways Vitamin D positively promotes health I routinely (for the last 15 or so years) take 10,000 IU/day in summer (I am very fair, burn instantly in the sun, and old, so get little sun exposure) and take up to 20,000 IU/day in the winter. This keeps my 25-OH-vitamin D levels above 80ng/ml, considered by many experts to be optimal for immune function and longevity. Now we find that it also increases Klotho expression and levels in many cell types; another good reason to greatly exceed the FDA’s pitiful recommendations.

The second is exercise, particularly weight training, or sprint-like interval training. I have consistently trained with weights for coming up on 50 years, and at 82, work part time as a Trainer at Fitness19 gym in Simi Valley, CA. Most people guess my age about a decade low. I teach a simple, basic approach to staying strong and fit into advanced age, and coach clients on nutrition and supplementation to get the most out our remaining life span. A Google Scholar search on Exercise + Klotho brings up about 1000 studies to demonstrate that truth. In about a half hour, twice a week, almost everyone can radically improve their health-span and get more living out of life.